Skip to main content
. 2023 Apr 11;3(6):100298. doi: 10.1016/j.xgen.2023.100298

Figure 4.

Figure 4

Inference of TF activity and annotation of TF modules

(A) Heatmap representing the TF activities (row) for each meta cell (column). The TF activities were first calculated using the AUCell framework and then normalized between 0 and 1.

(B) Basic metrics of the TF-target regulons. The upper and bottom panels showed the distribution of number of targets per TF and numbers of TF regulators per target. Median values are labeled.

(C) Heatmap depicting the TF-TF correlations. Hierarchical clustering was first made, and modules were detected by cutting the tree to K groups (K = 10 here).

(D) The activity of TFs in each module in each cell class. The TF modules were then annotated based on the observed specificity of the module. Previously studied TFs are also listed. The center line of the boxplot shows the median of the data; the box limits show the upper and lower quartiles; the whiskers show 1.5 times interquartile ranges.