Table 1.
Inter-group comparison of patient characteristics
| Characteristics | CAA (n = 67) | Probable Alzheimer’s disease (n = 76) | MCI due to Alzheimer’s disease (n = 75) | MCI (n = 76) | HC (n = 78) | P-value |
|---|---|---|---|---|---|---|
| Age, years, median (IQR) | 75 (68–79) | 72 (60–77) | 72 (65–75) | 68 (57–74) | 58 (54–65) | <0.001 |
| Sex, female, n (%) | 27 (40.3%) | 39 (51.3%) | 37 (49.3%) | 33 (43.4%) | 30 (38.5%) | 0.43 |
| Prior medical history | ||||||
| Intracerebral haemorrhage, n (%) | 11 (16.4%) | 0 (0.0%) | 1 (1.3%) | 2 (2.6%) | 1 (1.3%) | <0.001 |
| Ischaemic stroke, n (%) | 19 (28.4%) | 9 (11.8%) | 1 (1.3%) | 13 (17.1%) | 7 (9.0%) | <0.001 |
| Transient ischaemic attack, n (%) | 3 (4.5%) | 5 (6.6%) | 0 (0.0%) | 2 (2.6%) | 3 (3.8%) | 0.20 |
| Subarachnoid haemorrhage, n (%) | 2 (3.0%) | 0 (0.0%) | 0 (0.0%) | 2 (2.6%) | 0 (0.0%) | 0.16 |
| Arterial hypertension, n (%) | 56 (83.6%) | 51 (67.1%) | 48 (64.0%) | 53 (69.7%) | 49 (62.8%) | 0.06 |
| Diabetes mellitus, n (%) | 17 (25.4%) | 8 (10.5%) | 10 (13.3%) | 9 (11.8%) | 11 (14.1%) | 0.10 |
| Prior medication | ||||||
| Antiplatelet therapy, n (%) | 27 (40.3%) | 22 (28.9%) | 29 (38.7%) | 23 (30.3%) | 19 (24.4%) | 0.19 |
| Oral anticoagulants, n (%) | 5 (7.5%) | 6 (7.9%) | 1 (1.3%) | 5 (6.6%) | 1 (1.3%) | 0.10 |
| Statins, n (%) | 23 (34.3%) | 23 (30.3%) | 28 (37.3%) | 22 (28.9%) | 15 (19.2%) | 0.14 |
| Clinical features | ||||||
| Aggressive behaviour, n (%) | 2 (3.0%) | 5 (6.6%) | 2 (2.7%) | 0 (0.0%) | 0 (0.0%) | 0.04 |
| Gait disturbance, n (%) | 16 (23.9%) | 5 (6.6%) | 3 (4.0%) | 8 (10.5%) | 1 (1.3%) | <0.001 |
| Recurrent falls, n (%) | 9 (13.4%) | 3 (3.9%) | 3 (4.0%) | 8 (10.5%) | 4 (5.1%) | 0.09 |
| Transient focal neurologic episodes, n (%) | 8 (11.9%) | 4 (5.3%) | 0 (0.0%) | 2 (2.6%) | 2 (2.6%) | <0.01 |
Compared by Kruskal–Wallis H-test, Pearson’s χ2-test, or the Freeman–Halton extension of the Fisher’s exact test. Abbreviations: CAA, Cerebral amyloid angiopathy; CI, confidence intervals; HC, healthy controls; IQR, Interquartile range; MCI, mild cognitive impairment. This table is an abbreviated version of the patient characteristics. For the complete table, please see supplemental table 1.