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. 2023 May 4;3(6):100316. doi: 10.1016/j.xgen.2023.100316

Figure 5.

Figure 5

Genomic fine-mapping of the TPCN1 locus

(A) Scatterplot showing the beta regression coefficients of common variants (MAF ≥ 1%) at the TPCN1 locus in the Chia et al. LBD GWAS (y axis)12 and Bellenguez et al. Alzheimer’s disease GWAS (x axis).22

(B) Beta-beta plot comparing the TPCN1 locus variants in the Chia et al. LBD GWAS (y axis)12 with the Nalls et al. Parkinson’s disease GWAS results (excluding 23&Me data; x axis).23

(C) Single-nucleus RNA sequence analysis of the TPCN1 deletion-tagging SNP rs6489896 identified a significant cis-eQTL for RITA1 in excitatory neurons.