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. 2023 May 30;15(6):1280. doi: 10.3390/v15061280

Figure 2.

Figure 2

Wuhan S1 SARS-CoV-2 sVNT. (A) Binding of biotinylated hACE2 to conjugated SARS-CoV-2 Wuhan S1 protein. (B) Inhibition of hACE2—SARS-CoV-2 S1 interaction by a selected number of sera from patients with COVID-19. (C) Specificity of the SARS-CoV-2 sVNT in singleplex format. The COVID-19 group (in blue) consisted of sera from patients (n = 54), and the negative control group (in red) consisted of pre-COVID-19 blood donor sera (n = 200). Data were analyzed using the Mann–Whitney test, and a p-value < 0.05 was considered significant. **** = p-value < 0.0001. sVNT—surrogate virus neutralization test; BI—binding inhibition; S1—domain of the spike protein involved in receptor binding; hACE2—human angiotensin-converting enzyme 2; dotted line indicates a cut-off of 36%; black horizontal lines indicate median.