Table 4.

Subgroup analyses of the mediating role of serum α-Klotho in the association between standardized overall HEI 2015 scores and eGFR in the NHANES.

	Weighted β Coefficient (95%CI) for eGFR
Mediator: α-Klotho	Total Effect	Direct Effect	Indirect Effect	Proportion Mediated % (95% CI)
Age (years)
40–59	0.59 (0.21, 0.96) *	0.56 (0.18, 0.93) *	0.03 (−0.01, 0.06)	-
60–79	1.30 (0.87, 1.77) *	1.20 (0.76, 1.67) *	0.10 (0.04, 0.16) *	7.6 (3.2, 14.0) *
Sex
Male	0.92 (0.49, 1.28) *	0.83 (0.41, 1.20) *	0.09 (0.04, 0.14) *	9.6 (4.5, 20.0) *
Female	0.90 (0.50, 1.32) *	0.88 (0.48, 1.29) *	0.03 (−0.01, 0.06)	-

Model adjusted for age, sex, race, education, income, total energy intake, alcohol intake, smoking, physical activity, BMI, self-reported hypertension, self-reported diabetes, and self-reported cardiovascular disease; * p < 0.05.