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. 2023 May 12;3(6):1623–1633. doi: 10.1021/jacsau.3c00084

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(a) Illustration of NP-CT with PEG-400 and PEG-5k linkers. Shorter PEG linkers present a lower steric hindrance to binding and increase the probability of preserving the orientation of the grafted protein, while longer PEG linkers are bulkier and allow for the “burying” of binding domains due to their flexibility. (b) Comparison of association profiles between NP-CT-PEG400 and NP-CT-PEG5k obtained by QCM on a surface with ∼20 Hz of ApoER2. Injections of 20 and 200 μg/mL NPs were used in each case; no binding was observed for NP-CT-PEG5k.