Table 5.

Coumarins identified in various parts of C. medica L.

Compounds	Formula	Structure	Extraction Method	Method Analyses	Part of the Plant	Quantitative	References
Oxypeucedanin hydrate	C16H16O6		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	2.03–21.30 g/100 g DW	[43]
Scoparone (6,7-dimethoxycoumarin)	C11H10O4		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
			PLE MeOH	HPLCDAD	fructus	38.79 µg/mL	[40]
			UAE	HPLC–Q/TOF–MS	fructus	-	[35]
Skimmin	C15H16O8		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
Haploperoside A	C22H28O13		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
Leptodactylone	C11H10O5		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
Herniarin (7-methoycoumarin)	C10H8O3		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
Isomeranzin	C15H16O4		UAE	HPLC–Q/TOF–MS	fructus	-	[35]
Scopoletin	C10H8O4		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
			PLE MeOH	HPLC–DAD	fructus	53.56 µg/mL	[40]
Isoscopoletin	C10H8O4		PLE MeOH	HPLC–DAD	fructus	63.06 µg/mL	[40]
Umbelliferone (7-hydroxycoumarin)	C9H6O3		MeOH under reflux	EI-MS, HR–EI–MS	fresh fruit	-	[43]
			PLE MeOH	HPLC–DAD	fructus	40.23 µg/mL	[40]
Nordentatin	C19H20O4		MeOH under reflux	EI–MS, HR–EI–MS	fresh fruit	-	[43]
			Maceration in acetone	COSY, NOESY, HMQC, HMBC, HR–ESI–MS	root bark, stem bark	-	[36]
2-pyrone	C5H4O2		Maceration and UAE MeOH	GC–MS	exocarp, mesocarp	23.4–33.1%	[54]
Citropten (5,7-dimethoxycoumarin)	C11H10O4		PLE MeOH	HPLC–DAD	fructus	106.47 µg/mL	[40]
			MeOH under reflux	HR–EI–MS1	fresh fruits	0.16–0.45 mg/g DW	[43]
			Maceration of peel with n-hexane at room temperature	GC–MS	fructus	12.64%	[50]
			UAE	HPLC–Q/TOF–MS	fructus	0.18–0.45 mg/g DW	[35]
Bergapten	C12H8O4		PLE MeOH	HPLC–DAD	fructus	35.07 µg/mL	[40]
			UAE	HPLC–Q/TOF–MS	fructus	-	[35]
			Maceration MeOH	ESI–HR, EI–MS, HMQC, HMBC	bark	-	[37]
Citrumedin-B	C24H28O4		Acetone at room temperature	COSY, NOESY, HMQC, HMBC, HR–ESI–MS	root bark, stem bark	-	[36]
Xanthyletin	C14H12O3		PLE MeOH	HPLC–DAD	fructus	-	[40]
			UAE with CHCl3	MEKC (micellar electrokinetic capillary chromatography)	root bark	-	[60]
Xanthoxyletin	C15H14O4		UAE with CHCl3	MEKC (micellar electrokinetic capillary chromatography)	root bark	-	[60]
5,8-dimethoxhypsoralene	C12H8O4		Maceration MeOH	ESI–HR, EI–MS, HMQC, HMBC	bark	-	[37]