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Therapeutic mechanisms of the MPEI/pCAR-IFN-γ nanocomplex. (A) Schematic illustrating the delivery of combinatorial gene encoding ALK-specific CAR and IFN-γ plasmid DNA (pCAR-IFN-γ) using MPEI to induce CAR-M1 macrophages in vivo, as well as, the anti-tumoral mechanisms of CAR-M1 macrophages. (B) Transgene construct of the combinatorial gene expressing anti-ALK CAR and IFN-γ (Kang et al., 2021). Copyright© 2021, Wiley.
