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. 2023 Jun 14;11:1211687. doi: 10.3389/fbioe.2023.1211687

TABLE 1.

Summary of CAR-M-based preclinical studies and clinical trials.

Target antigen Intracellular domain Gene delivery Macrophage source Application strategy Clinical trials References
CEA CD64 adenoviral vector Monocytes derived from human peripheral blood mononuclear cells (PBMCs) in vitro - Biglari et al. (2006)
CD19 CD22 Fc Gamma lentiviral vector J774A.1 Macrophages Bone marrow derived macrophages (BMDMs) in vitro - Morrissey et al. (2018)
Megf10
MerTK
Bai1
CD3zeta
PI3K
HER2 CD147 lentiviral vector Raw264.7 in vitro - Zhang et al. (2019)
CCR7 TLR2 lentiviral vector RAW264.7 in vitro - Niu et al. (2021)
TLR4
TLR6
MerTK
4-1BB-CD3ζ
CD19 ALK CD28CD3ζ Non-viral vector: jetPEI-macrophage (MPEI) RAW264.7 in vivo - Kang et al. (2021)
M2 BMDM
M2 TAMs
CD133 CD3ζ Non-viral vector: nanoporter (NP)-hydrogel THP-1 bone marrow-derived macrophages (BMDMs) RAW 264.7 in vivo - Chen et al. (2022a)
CD19 CD3ζ Non-viral vector: Lipid nanoparticle (LNP) RAW264.7 bone marrow-derived macrophages (BMDMs) in vitro - Ye et al. (2022)
Mesothelin CD3ζ MaxCyte GT System™ Peripheral blood monocytes in vitro NCT03608618 Hung et al. (2018)
CD19 CD3ζ adenoviral vector (Ad5f35) THP-1 monocyte-derived macrophages in vitro NCT04660929 Klichinsky et al. (2020)_
Mesothelin
 HER2
  HER2 CD3ζ adenoviral vector (Ad5f35) Peripheral blood monocytes in vitro - Gabitova et al. (2021)
  CD19 meso CD86-FcγR I lentiviral vector iPSCs from peripheral blood mononuclear cells (PBMC) in vitro - Zhang et al. (2020)
  CEA CD28CD3ζ lentiviral vector THP-1 hematopoietic stem and progenitor cells (HSPCs) in vitro - Paasch et al. (2022)