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. 2023 Jun 16;16(6):889. doi: 10.3390/ph16060889

Table 2.

Medications commonly prescribed for pediatric gastrointestinal complaints with actionable CPIC®/and/or DPWG guidelines.

Actionable
CPIC® and/or Dutch Working Group Guidelines Available		 Not Actionable
Lack Significant HEPATIC Metabolism/Predominant Renal Elimination		 More Research Needed
No Current Guidelines or Recommendations
* Proton Pump Inhibitors (CYP2C19)
* Selective Serotonin Reuptake Inhibitors (CYP2C19, CYP2D6, CYP2B)
* Amitriptyline (CYP2C19, CYP2D6)
* Ondansetron (CYP2D6)
* Tacrolimus (CYP3A5)
* Azathioprine (TPMT, NUDT15)
* Mercaptopurine (TPMT, NUDT15)		 Miralax
Lactulose
Famotidine
Fluconazole
Ursodiol
Biologics		 Budesonide (CYP3A4, CYP3A5)
Fluticasone (CYP3A4)
Erythromycin (CYP3A4)
Lorazepam (UGT2B15)
Diphenhydramine (CYP2D6)
Sirolimus (CYP3A4, CYP3A5)
Micafungin (CYP3A4, COMT)
Cimetidine (CYP1A2, CYP2C19)
Cyproheptadine (multiple UGTs)
Prednisone (CYP3A4)
Mycophenolate mofetil (multiple UGTs, SLCO1B1)

* Denotes where oral liquid formulations or extemporaneous preparations of medications with actionable guidelines may be available for easier dosage adjustments based on weight and pharmacogenetic information. For medication classes—select medications may have oral liquid formulations/extemporaneous preparations.