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. 2023 Jan 4;25:e5. doi: 10.1017/erm.2022.43

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© The Author(s) 2023

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.

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Fig. 2. — LQTS pathogenic hotspots in the subunits of representative ion channels including Kv7.1, Kv11.1, Nav1.5 and Cav1.2. (a) Predicted topology of Kv7.1 α subunit with the location of mutations associated with LQTS1. (b) Predicted topology of Kv11.1 α subunit with mutation sites related to LQTS2. (c) Predicated topology of Nav1.5 α subunit with the location of genetic mutations associated with LQTS3. (d) Predicted topology of Cav1.2 α1c subunit with the mutation positions related to LQTS8. Red dots indicate potential mutation positions in the respective ion channel proteins.