Figure 4.

Micrograph of the H&E-stained sections of the liver tissues of (A) diabetic rats treated with L. plantarum cell lysate showing hepatocytes with microvesicular (black circle) and macrovesicular steatosis (dotted arrow), normal hepatocytes (H), and inflammatory infiltration (steatohepatitis) (In). (B) The diabetic rats treated with L. plantarum intact cells showed normal morphology in most hepatocytes (H), a few hepatocytes showing large fat vacuoles (dotted arrow), as well as a few hepatocytes showing microvesicular fatty changes (black circle). Notice the congested hepatic sinusoids (CS) and the inflammatory infiltrate (In). (C) The diabetic rats treated with a low dose of S. costus show that most hepatocytes seem normal, some appear vacuolated with small steatotic vacuoles (black circle), and very few hepatocytes exhibit large steatotic vacuoles. Notice the inflammatory cell infiltration (In) between hepatocytes and the portal area’s connective tissue. (D) The diabetic rats treated with a high dosage of S. costus showed normal hepatic architecture; some hepatocytes exhibited microvesicular fatty change (black circle) and a few congested hepatic sinusoids (CS) (Stain: H&E; 100×).