Table 2.

Hazard ratios for vitamin D in relation to major cardiovascular events

Outcome*	Vitamin D (n=10 658)	Placebo (n=10 644)	HR (95% CI)¶
Major event†	637 (6.0)	699 (6.6)	0.91 (0.81 to 1.01)
Myocardial infarction	194 (1.8)	238 (2.2)	0.81 (0.67 to 0.98)
Coronary revascularisation‡	413 (3.9)	462 (4.3)	0.89 (0.78 to 1.01)
Stroke§	172 (1.6)	173 (1.6)	0.99 (0.80 to 1.23)
Haemorrhagic stroke	40 (0.4)	41 (0.4)	0.97 (0.63 to 1.50)
Ischaemic stroke	116 (1.1)	113 (1.1)	1.03 (0.79 to 1.33)

Data are numbers (%).

95% CI=95% confidence interval.

^*The number (%) of people with at least one event.

^†Composite endpoint including myocardial infarction, stroke, and coronary revascularisation. The number of people who experienced at least one major event is less than the total of the numbers presented for myocardial infarction, stroke, and coronary revascularisation because participants could experience more than one type of event.

^‡Composite endpoint including percutaneous coronary intervention (insertion of stent or balloon, artherectomy, thromboectomy, and endarterectomy) or coronary artery bypass grafting.

^§Stroke includes diagnosis code I64 (unspecified) and therefore exceeds the total number of ischaemic and haemorrhagic strokes.

^¶Estimated using flexible parametric survival models that included age, sex, and state of residence at baseline. The baseline log cumulative hazard function was modelled using restricted cubic spline with two internal knots (placed at the 33rd and 67th percentiles of the uncensored log survival times).