Table 1.

The advantages and the disadvantages of various nanoformulations for drug delivery.

	Polymer-Based Nanosystems				Lipid-Based Nanosystems		Surfactant-Based Nanosystems		Cyclodextrin-Based Nanoparticles	Inorganic Nanoparticles
	Polymeric Micelles	Polymeric Nanoparticles	Hydrogels	Polymersomes	Liposomes	SLN-NLC	Niosomes	Nanoemulsions
Advantages
Biocompatibility	++	++	++	++	+++	+++	++	+++	+++	+
Biodegradability	+	++	+++	++	++	++	++	++	+++	+
High Loading efficiency	++	++	+++	+++	++	+++	++	+++	++	+
Chemical versatility	+++	+++	+	+++	+	+	+	+	+	+
Physicochemical stability	+++	+++	+++	+++	+	++	++	++	++	+++
Controlled release properties	+++	+++	++	+++	++	++	++	++	++	++
Administration by different routes	++	++	+	++	+++	++	++	++	++	++
Stimuli responsiveness	+++	++	+++	++	+	+	+	+	+	+++
Improve of ADME(T) profile	+++	+++	+	++	++	++	++	++	++	+
Targeting	++	++	+	+	+	+	+	+	+	+++
Imaging	+	+	+	+	+	+	+	+	+	+++
Theragnostic	+	+	+	+	+	+	+	+	+	+++
Precision medicine	+	+	+	+	+++	+	+	+	+	++
Disadvantages
Nanotoxicity	++	++	+	++	++	++	++	+	+	+++
High cost	+	+	+	++	++	++	++	+	+	+++
Limitations in scale-up	+	+	+++	++	++	++	++	+	++	+++
Immunogenicity	++	++	+	++	+	+	+	+	+	+++
Lack in regulatory framework	++	++	+++	+++	++	++	+++	+	+++	++

SLN-NLC: Solid lipid nanoparticles-Nanostructured Lipid Carriers; ADME(T): Absorption, Distribution, Metabolism, Excretion and Toxicology. High: +++, Medium: ++, Low: +.