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. 2023 May 22;34:101683. doi: 10.1016/j.tranon.2023.101683

Fig. 1.

Fig. 1

ALKBH5 expression is downregulated in CRC and strongly correlates with patient prognoses. a Pan-cancer analysis of ALKBH5 expression levels in TIMER database. b Expression of ALKBH5 in TCGA CRC cohort. c IHC showing representative images of ALKBH5 protein staining in tissue microarrays constructed from 56 CRC tissues and paired adjacent paraneoplastic tissues and statistical analysis. d Detection of mRNA levels of ALKBH5 in human normal colonic mucosal erithelial cells (NCM460) and CRC cancer cells (HCT116, SW620, SW480) by qRT-PCR. e Protein expression levels of ALKBH5 in normal NCM460 cells and three CRC cell lines. f Kaplan-Meier survival analysis shows the relationship between expression of ALKBH5 and overall patient survival time.