Table 5.
Performance of monomer weight model in the discovery cohort using 11 fucose-dependent features derived from N-glycopeptides that achieved FDR<0.05 in age- and sex-adjusted Cox regression analysis.
| Classifier prediction | Events/N | Median OS (95% CI) | HR (95% CI) | P-value |
|---|---|---|---|---|
| Full discovery cohort (n=202) | ||||
| Likely to benefit | 96/180 | 50.4 (36.1, 75.7) | Reference | |
| Unlikely to benefit | 17/22 | 3.7 (2.8, 12.8) | 3.1 (1.9, 5.3) | 1.6×10-5 |
| Discovery: training set (n=79) | ||||
| Likely to benefit | 36/70 | 54.2 (37.9, NR) | Reference | |
| Unlikely to benefit | 6/9 | 1.8 (1.2, NR) | 2.9 (1.2, 7.0) | 0.016 |
| Discovery: validation set (n=59) | ||||
| Likely to benefit | 27/53 | 54.8 (24.8, NR) | Reference | |
| Unlikely to benefit | 5/6 | 3.2 (2.9, NR) | 3.8 (1.4, 10.0) | 6.7×10-3 |
| Discovery: test set (n=64) | ||||
| Likely to benefit | 33/57 | 39.4 (17.3, NR) | Reference | |
| Unlikely to benefit | 6/7 | 5.1 (4.1, NR) | 3.5 (1.4, 8.5) | 6.6×10-3 |
NR, not reached.