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. 2023 Jun 14;14:1145481. doi: 10.3389/fimmu.2023.1145481

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Copyright © 2023 Li, Wang, Wang, Cao, Pan, Huang, Wan, Zhang, Huang, Jin and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTPRC was pivotal in CD8 T cell infiltration in BRCA. (A) Identifying both drug score related and immune cell infiltration related ICD-TDGs in four independent cohort (TCGA-BRCA, GEO cohort-4037, GEO cohort-TNBC, GEO cohort-1, GEO cohort-2), then identifying BIRC3, CCR7, CD79B, IKZF3 and PTPRC were the common feature genes in four data cohorts. All of those five genes were positively corelated to CD8 T cell and γδ T cell, while they were negatively corelated to M0. (B) Impact analysis in XGBoost Modeling; (C) GO analysis of PTPRC-related genes; (D) Molecular pathways of PTPRC-related genes (GeneMANIA: http://genemania.org); (E) Linear curve between PTPRC and markers of CD8+ T cells (CD8, CD3D, CD3E, CD3G); (F) Roles of the PTPRC expression level in prognosis of breast cancer with or without drug treatments.