Figure 11.

PTPRC regulated CD8 T cell infiltration and TEX. (A) Local TNBC cohort was performed 14-ICD-TDGs-based drug sensitivity prediction, and the relationships between PTPRC and markers of CD8+ T cells, and between PTPRC and drug scores were explored; (B) Multiple immune inflorescence staining was performed in breast cancer tissues, amongst which pink represented IKZF3, green represented CD8, red represented PTPRC. And the results displayed the quantity of (C) IKZF3+ cells were not related with CD8+ T cells, while (D) PTPRC+ cells were positively related with CD8+ T cells (R=0.85, p=1.7e-5); TR-qPCR assays of siRNA experiments in TNBC cell lines, included (E) MBA-MD-453 and (F) MBA-MD-231; (G) Western blot assays displayed siRNA explements results, and sequence 1(SH1) and sequence-2 (SH2) were both efficient in decreased the intracellular expression level of PTPRC in TNBC cell lines; (H, I) siRNA and (J, K) recombination plasmid were applied to decrease the expression of PTPRC to explore the roles of PTPRC in regulating IL2/6 and PDL1. *p < 0.05; **p < 0.01; ***p < 0.001.