Table 3.
Cytokines and Peptides combined in main study.
| Rv0849-13 | Rv2031c-6 | Rv2031c-15 | Rv2693-07 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LTBI | ATBD | p * | LTBI | ATBD | p * | LTBI | ATBD | p * | LTBI | ATBD | p * | |
| EGF | 1.65 (0.0–9.04) | 0 (0.0–22.73) | 0.504 | 1.57 (0.0–6.71) | 7.78 (0.0–28.99) | 0.030 | 1.76 (0.0–10.53) | 2.47 (0.0–20.19) | 0.554 | 0 (0.0–4.95) | 6.17 (0.0–22.15) | 0.001 |
| EOTAXIN | 0 (0.0–3.29) | 0 (0.0–2.53) | 0.513 | 0.49 (0.0–3.31) | 0 (0.0–3.29) | 0.362 | 0.74 (0.0–2.6) | 0 (0.0–3.41) | 0.630 | 0.49 (0.0–1.7) | 0 (0.0–3.29) | 0.821 |
| FGF-2 | 0.0 (0.0–0.0) | 0 (0.0–1.96) | 0.409 | 0.0 (0.0–0.0) | 0 (0.0–1.75) | 0.682 | 0 (0.0–1.16) | 0 (0.0–2.37) | 0.650 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.984 |
| Flt | 0 (0.0–1.21) | 0 (0.0–1.22) | 0.546 | 0 (0.0–0.72) | 0 (0.0–1.56) | 0.307 | 0 (0.0–1.21) | 0 (0.0–1.12) | 0.593 | 0 (0.0–1.02) | 0 (0.0–0.73) | 0.331 |
| Fractalkine | 11.77 (0.0–21.35) | 0 (0.0–13.07) | 0.113 | 10.96 (0.0–19.53) | 8.04 (0.0–18.30) | 0.549 | 10.39 (0.0–13.07) | 0 (0.0–13.07) | 0.248 | 11.77 (0.0–19.53) | 0 (0.0–14.27) | 0.081 |
| G-CSF | 0 (0.0–2.14) | 0.41 (0.0–0.86) | 0.117 | 0.41 (0.0–2.37) | 0 (0.0–2.14) | 0.170 | 0 (0.0–2.14) | 0 (0.0–1.88) | 0.673 | 0 (0.0–1.89) | 0.0 (0.0–0.0) | 0.072 |
| GM-CSF | 0.2 (0.0–0.92) | 0.12 (0.0–1.17) | 0.761 | 0.1 (0.0–1.22) | 0.34 (0.0–1.53) | 0.602 | 0.04 (0.0–0.89) | 0.19 (0.0–1.7) | 0.422 | 0.2 (0.0–1.33) | 0.37 (0.0–1.19) | 0.894 |
| GRO | 32.21 (9.47–153.24) | 60.57 (1.08–230.83) | 0.563 | 45.57 (8.05–139.76) | 105.35 (21.05–579.55) | 0.017 | 21.05 (1.52–78.48) | 37.51 (3.05–466.44) | 0.136 | 33.11 (9.28–94.95) | 77.50 (21.21–259.76) | 0.036 |
| IFNa2 | 0.54 (0.0–2.05) | 0 (0.0–2.11) | 0.716 | 0 (0.0–1.23) | 0.53 (0.0–2.27) | 0.307 | 0 (0.0–1.23) | 0.27 (0.0–1.94) | 0.599 | 0 (0.0–1.23) | 0 (0.0–1.20) | 0.707 |
| IFNg | 0.0 (0.0–0.0) | 0 (0.0–0.23) | 0.262 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.763 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.528 | 0 (0.0–0.37) | 0.0 (0.0–0.0) | 0.166 |
| IL-10 | 0 (0.0–12.43) | 2.55 (0.0–16.13) | 0.384 | 1.7 (0.0–17.37) | 2.84 (0.0–13.55) | 0.929 | 1.26 (0.0–13.42) | 0.31 (0.0–12.79) | 0.833 | 2.71 (0.0–18.44) | 2.78 (6.08–61.70) | 0.932 |
| IL-12p40 | 0 (0.0–0.84) | 0 (0.0–0.09) | 0.043 | 0 (0.0–1.47) | 0 (0.0–0.70) | 0.123 | 0 (0.0–0.76) | 0 (0.0–0.78) | 0.786 | 0 (0.0–0.63) | 0.0 (0.0–0.0) | 0.425 |
| IL-12p70 | 0 (0.0–0.37) | 0 (0.0–0.60) | 0.173 | 0 (0.0–0.48) | 0.21 (0.0–0.96) | 0.050 | 0 (0.0–0.49) | 0.53 (0.0–1.47) | 0.029 | 0 (0.0–0.33) | 0.27 (0.0–1.28) | 0.023 |
| IL-13 | 0.63 (0.0–3.11) | 1.42 (0.0–4.22) | 0.428 | 1.04 (0.0–3.14) | 0.39 (0.0–3.25) | 0.348 | 0 (0.0–1.33) | 0.60 (0.0–4.23) | 0.117 | 0 (0.0–2.08) | 1.68 (0.0–3.94) | 0.022 |
| IL-15 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.370 |
| IL-17 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.849 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.710 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.293 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.442 |
| IL-1a | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.071 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.029 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.029 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.006 |
| IL-1B | 0.0 (0.0–0.0) | 0 (0.0–0.59) | 0.408 | 0.0 (0.0–0.0) | 0 (0.0–1.34) | 0.121 | 0.0 (0.0–0.0) | 0 (0.0–0.65) | 0.015 | 0.0 (0.0–0.0) | 0 (0.0–0.32) | 0.025 |
| IL-1RA | 0.48 (0.0–1.87) | 5.57 (0.0–84.45) | 0.001 | 0.47 (0.0–1.42) | 4.51 (0.0–84.50) | 0.006 | 0.51 (0.0–1.18) | 13.55 (0.26–73.2) | 0.001 | 0.06 (0.0–1.87) | 4.78 (0.0–69.27) | 0.001 |
| IL-2 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.426 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.649 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.373 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.937 |
| IL-22 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 |
| IL-3 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.265 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 1.000 |
| IL-4 | 0 (0.0–6.05) | 3.58 (0.0–8.24) | 0.349 | 0 (0.0–6.05) | 2.47 (0.0–13.55) | 0.129 | 0 (0.0–8.15) | 0.28 (0.0–8.73) | 0.469 | 0.28 (0.0–6.05) | 2.61 (0.0–8.45) | 0.392 |
| IL-5 | 0 (0.0–0.05) | 0 (0.0–0.10) | 0.479 | 0 (0.0–0.05) | 0 (0.0–0.08) | 0.435 | 0 (0.0–0.05) | 0 (0.0–0.05) | 0.194 | 0 (0.0–0.05) | 0 (0.0–0.05) | 0.621 |
| IL-6 | 0 (0.0–1.1) | 0 (0.0–0.72) | 0.917 | 0 (0.0–3.46) | 0.14 (0.0–4.77) | 0.540 | 0 (0.0–0.57) | 0 (0.0–4.06) | 0.127 | 0 (0.0–1.11) | 0 (0.0–2.02) | 0.950 |
| IL-7 | 1.52 (0.0–3.39) | 0.72 (0.0–3.85) | 0.369 | 1.66 (0.0–2.89) | 1.46 (0.0–4.32) | 0.952 | 1 (0.0–2.55) | 0.95 (0.0–3.23) | 0.838 | 1.03 (0.0–1.96) | 1.52 (0.0–3.16) | 0.930 |
| IL-8 | 114.04 (30.14–404.76) | 182.12 (16.62–600.10) | 0.396 | 189.6 (26.91–441.22) | 368.65 (92.22–1611.75) | 0.041 | 66.98 (0.0–371.87) | 141.5 (30.32–954.13) | 0.059 | 168.23 (43.61–368.22) | 266.01 (123.42–1031.04) | 0.038 |
| IL-9 | 0 (0.0–1.32) | 0.92 (0.0–2.41) | 0.158 | 0.1 (0.0–1.15) | 0.63 (0.0–2.51) | 0.269 | 0 (0.0–1.02) | 0.26 (0.0–1.75) | 0.267 | 0.59 (0.0–1.93) | 0.23 (0.0–2.14) | 0.691 |
| IP-10 | 8.72 (0.0–15.01) | 1.09 (0.0–10.60) | 0.054 | 7.65 (1.15–20.67) | 6.39 (0.0–17.13) | 0.193 | 7.97 (0.0–12.31) | 3.44 (0.0–10.50) | 0.114 | 5.8 (0.0–16.68) | 3.58 (0.0–13.96) | 0.300 |
| MCP-1 | 46.87 (0.0–408.52) | 361.73 (48.60–1447.92) | 0.003 | 77.6 (0.0–815.13) | 465.28 (11.51–1267.78) | 0.105 | 82.22 (0.0–819.08) | 120.37 (0.0–882.54) | 0.989 | 42.15 (0.0–656.25) | 468.47 (0.0–1689.57) | 0.029 |
| MCP-2 | 0.64 (0.0–2.31) | 1.23 (0.0–3.02) | 0.517 | 0.94 (0.0–3.23) | 1.22 (0.0–4.38) | 0.961 | 0.64 (0.0–1.64) | 1.08 (0.0–3.72) | 0.540 | 0.53 (0.0–1.91) | 0.38 (0.0–1.79) | 0.683 |
| MCP-3 | 14.93 (3.59–48) | 27.65 (6.29–79.52) | 0.268 | 14.13 (2.23–45.15) | 30.53 (9.46–132.49) | 0.033 | 10.89 (0.0–43.31) | 26.33 (8.84–52.16) | 0.078 | 12.92 (0.0–40.57) | 28.2 (6.08–61.70) | 0.079 |
| MDC | 9.66 (0.0–38.23) | 9.35 (0.0–54.15) | 0.474 | 5.48 (0.0–36.56) | 20.46 (2.31–48.27) | 0.091 | 2.68 (0.0–25.66) | 7.05 (0.0–25.16) | 0.512 | 0 (0.0–7.26) | 6.80 (0.0–27.95) | 0.002 |
| MIP-1a | 0.91 (0.0–11.17) | 1 (0.0–12.01) | 0.843 | 4.56 (0.0–12.92) | 11.42 (0.0–27.52) | 0.663 | 0 (0.0–3.85) | 1.03 (0.0–11.36) | 0.105 | 0 (0.0–3.09) | 0 (0.0–6.49) | 0.302 |
| MIP-1B | 0.71 (0.0–8.36) | | | 0.965 | 7.09 (0.0–13.81) | 8.99 (0.0–18.61) | 0.547 | 0 (0.0–4.74) | 0 (0.0–7.98) | 0.502 | 0 (0.0–3.64) | 0 (0.0–7.52) | 0.621 |
| sCD40L | 3.305 (0.0–6.54) | 3.71 (0.0–13.14) | 0.386 | 2.48 (0.0–4.19) | 2.94 (0.0–13.81) | 0.242 | 1.45 (0.0–4.63) | 2.52 (0.0–9.94) | 0.355 | 0.78 (0.0–3.49) | 2.88 (0.0–10.37) | 0.141 |
| TGF a | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.113 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.113 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.113 | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.113 |
| TNF B | 0.06 (0.0–0.12) | 0.06 (0.0–0.12) | 0.696 | 0 (0.0–0.06) | 0.06 (0.0–0.13) | 0.064 | 0 (0.0–0.06) | 0.06 (0.0–0.13) | 0.029 | 0 (0.0–0.06) | 0 (0.0–0.12) | 0.361 |
| TNFa | 0.6 (0.0–4.28) | 0.33 (0.0–4.01) | 0.986 | 1 (0.0–3.61) | 1.04 (0.0–3.50) | 0.681 | 0 (0.0–1.65) | 0.06 (0.0–1.87) | 0.453 | 0.84 (0.0–4.42) | 0.04 (0.0–2.23) | 0.290 |
| VEGF | 1.48 (0.0–4.26) | 0.33 (0.0–6.45) | 0.795 | 0 (0.0–4.78) | 0.88 (0.0–7.52) | 0.345 | 1.14 (0.0–4.86) | 0 (0.0–5.75) | 0.764 | 1.33 (0.0–4.49) | 1.02 (0.0–6.07) | 0.857 |
Median (Q1–Q3). * Mann–Whitney test. Number of samples = 166.