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. Author manuscript; available in PMC: 2023 Dec 22.
Published in final edited form as: J Med Chem. 2022 Dec 2;65(24):16510–16525. doi: 10.1021/acs.jmedchem.2c01380

Figure 1. The acetyl-CoA carboxylase (ACC) reaction and ACC inhibitors.

Figure 1.

A) Biotin carboxylase (BC) catalyzes the ATP-dependent carboxylation of biotin which is covalently tethered to biotin carboxyl carrier protein (BCCP). The carboxybiotin is then transferred to the carboxyltransferase domain (CT) by BCCP, where acetyl-CoA is carboxylated to form malonyl-CoA. B) Pyridopyrimidine 1 (IC50 < 5 nM)12 and aminooxazole 2 (IC50 125 nM)13 are biotin carboxylase (BC) inhibitors. The natural product moiramide B (3, IC50 6 nM) inhibits the carboxyltransferase (CT) domain.14