Table 3:
Post-antibiotic effect (PAE) against E. coli ΔtolC + PMBN
| Compound | MIC (μM) | PAE (h)a | ||
|---|---|---|---|---|
| 8x | 16x | 32x | ||
| 15 | 0.78 | 1.9 ± 0.2 | 2.2 ± 0.3 | 3.8 ± 0.2 |
| 16 | 0.78 | 1.0 ± 0.2 | 1.2 ± 0.3 | 2.6 ± 0.09 |
| 17 | 0.39 | 1.7 ± 0.3 | 1.7 ± 0.2 | 3.4 ± 0.2 |
| 18 | 0.78 | 1.2 ± 0.4 | 1.8 ± 0.1 | 3.4 ± 0.02 |
| 19 | 1.56 | 2.1 ± 0.1 | 2.6 ± 0.07 | 3.6 ± 0.07 |
| 20 | 1.56 | 1.9 ± 0.3 | 3.8 ± 0.3 | 4.6 ± 0.2 |
a
The PAE was calculated using a standard procedure in which the time required for the bacteria to recover 1 log after washing out the inhibitor was compared to the culture treated with the vehicle (DMSO). Experiments were performed in triplicate, and the reported values are the average of the three independent experiments with the errors representing the standard deviation from the mean.