Table 2.

Clinical data of the patients. Associated pathologies of the fetus and the mother, smoking status, and reason for abortion.

Patient ID	Associated fetal pathology	Associated pathology of the mother	Smoker mother	Reason for abortion
Patient 1	• Craniofacial dysmorphism • Position anomalies at the upper and lower limbs	Hypothyroidism	yes	Increased number of malformations
Patient 2	• Craniofacial dysmorphism • Meckel diverticulum	Lumbar discopathy and radiculopathy	No	Teratogenic risk of the medication
Patient 3	• Macrocephalus • Spina bifida • Lumbar kyphosis • Varus equine of the lower limbs bilaterally • Intrauterine growth restriction	No	No	Increased number of malformations
Patient 4	• Spina bifida with myeloschisis • Chiari II malformation • Omphalomesenteric duct remnants	No	No	Increased number of malformations
Patient 5	Unilateral polymicrogyria	No	Yes	Spontaneous abortion
Patient 6	Meckel diverticulum	No	No	Ventriculomegaly