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. 2023 Jun 14;13:1194254. doi: 10.3389/fcimb.2023.1194254

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Copyright © 2023 Conte, Brunetti, Marazzato, Longhi, Maurizi, Raponi, Palamara, Grassi and Conte

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Genomic composition of each S. aureus strain. (B) Relative abundance of the core, accessory, and unique genes. (C) Within-group diversity, measured by the Jaccard dissimilarity index. Values can range from 0 (i.e. the organisms share the same set of genes) to 1 (i.e. no genes in common). Comparisons between AD lesional strains and healthy carriers-related strains were carried out by Mann-Whitney U-test, considering a p-value ≤ 0.05 as statistically significant. (****p-value ≤ 0.0001). (D) Between-diversity analysis expressed by the Principal coordinate analysis, based on the Jaccard index and performed on AD lesional skin and healthy carriers-related strains. For each Principal coordinate, the variance explained is expressed by numbers within parentheses.