Table 3.
Comparison of HCC associated factors in patients with MAFLD, NAFLD, and hepatitis C
| P value | ||||||
|---|---|---|---|---|---|---|
| Variables | HCV (n = 1154) | MAFLD (n = 222) | NAFLD (n = 101) | HCV vs MAFLD | HCV vs NAFLD | MAFLD vs NAFLD |
| AFP (ng/mL) | 20.7 (0.5–538,100) | 8.8 (1.0–1,089,700) | 9.5 (1.0–173,820) | < 0.001 | 0.001 | 0.996 |
| DCP (mAU/mL) | 63 (3.3–1,160,000) | 163 (11–593,860) | 235 (13–593,860) | < 0.001 | < 0.001 | 0.73 |
| Number of tumors | ||||||
| 1 | 609 (53) | 118 (53) | 58 (57) | 0.942 | 0.406 | 0.547 |
| 2,3 | 294 (25) | 53 (24) | 24 (25) | 0.673 | 0.811 | 1 |
| 4–9 | 95 (8) | 18 (8) | 6 (6) | 1 | 0.566 | 0.648 |
| 10- | 156 (14) | 33 (15) | 13 (13) | 0.595 | 1 | 0.732 |
| Maximum tumor size (mm) | ||||||
| < 20 | 407 (35) | 38 (17) | 14 (14) | < 0.001 | < 0.001 | 0.516 |
| 20–100 | 710(62) | 164 (74) | 76 (75) | < 0.001 | 0.007 | 0.891 |
| 100 < | 37 (3) | 20 (9) | 11 (11) | < 0.001 | < 0.001 | 0.684 |
| Clinical stage | ||||||
| Stage II ≤ | 848 (73) | 194 (87) | 86 (85) | < 0.001 | 0.009 | 0.599 |
| Stage III ≤ | 455 (39) | 109 (49) | 49 (49) | 0.009 | 0.09 | 1 |
| Stage IV ≤ | 176 (15) | 40 (18) | 16 (16) | 0.314 | 0.89 | 0.752 |
Data are expressed as medians with ranges for continuous variables and as total numbers and percentages for categorical variables. Differences between the groups are investigated using Fisher’s exact test for categorial variables or Mann–Whitney U test for continuous variables
AFP alpha-fetoprotein, DCP des-γ-carboxy prothrombin