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. 2023 Jun 28;21:419. doi: 10.1186/s12967-023-04294-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The scRNA-seq analysis of monocytes/macrophages in the livers. a 4738 monocytes/macrophages in the livers were re-clustered into 5 clusters according to their gene expression using Seurat v4.0 and the result was shown by tSNE. b The distribution of 5 monocytes/macrophages clusters among HCs, cirrhosis and ACLF patients. Clusters Mono1 and Mono4 were characteristically enriched in ACLF livers. c The proportions of 5 monocytes/macrophages clusters among HCs, cirrhosis and ACLF patients. The HCs and cirrhosis patients had similar proportions of each cluster, while the ACLF patients had high proportions of Mono1. d The heat map of the DE genes for each cluster. e The dotplot of the representative marker genes for each cluster. f The tSNE plots of marker genes for each cluster