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. 2023 Jun 28;21:419. doi: 10.1186/s12967-023-04294-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The targeted lipid metabolomics in the livers of cirrhosis and ACLF patients and stimulation test with α-LA. a The volcano plot of FFAs in the livers showed as the ACLF group over the cirrhosis group. 23 FFAs were increased in ACLF group while only 1 FFA was increased in cirrhosis group. b The 24 differentiated FFAs for each sample shown by Z score. c The metabolite sets enrichment analysis for the increased FFAs in ACLF livers. d The expression of TREM2 on selected CD14⁺ peripheral monocytes stimulated in vitro. The expression of TREM2 was significantly increased when stimulated with α-LA (60 μM) and LPS (100 ng/mL). (**p < 0.01, ****p < 0.0001, tested by paired t-test)