Table 2.
Association between SNPs and GDM
| SNP | Chr:bp a | Gene | Allele | MAF | Variant type |
Frequency | Genotype count | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/ Control | OR (95% CI) | P-allele | FDR | Case | Control | OR (95% CI) | P-genotype | FDR | ||||||
| rs61790001 | 1:59936155 | CYP2J2 | A/G | 0.153 | intron | 0.128/0.168 | 0.73 (0.62–0.86) | 0.0001 | 0.0094 | 22/196/720 | 45/451/1113 | 0.73 (0.61–0.86) | 0.0003 | 0.0026 |
| s144619025 | 1:59937579 | CYP2J2 | A/G | 0.035 | intron | 0.026/0.040 | 0.62 (0.45–0.87) | 0.0055 | 0.0835 | 0/48/890 | 4/122/1483 | 0.68 (0.48–0.97) | 0.0354 | 0.1105 |
| rs76271683 | 1:59953494 | CYP2J2 | G/A | 0.167 | intron | 0.186/0.157 | 1.23 (1.06–1.43) | 0.0075 | 0.0950 | 27/294/617 | 36/432/1142 | 1.27 (1.07–1.49) | 0.0048 | 0.0280 |
| rs57699806 | 8:27362587 | EPHX2 | A/G | 0.047 | missense | 0.054/0.042 | 1.30 (1.002–1.696) | 0.0479 | 0.1211 | 3/96/838 | 3/130/1475 | 1.46 (1.10–1.93) | 0.0087 | 0.0440 |
| rs34319290 | 8:27405207 | EPHX2 | A/G | 0.098 | downstream | 0.110/0.092 | 1.22 (1.01–1.47) | 0.0393 | 0.1115 | 11/183/740 | 9/275/1311 | 1.27 (1.04–1.56) | 0.0210 | 0.0751 |
| rs11572177 | 10:96797270 | CYP2C8 | G/A | 0.076 | intron | 0.085/0.070 | 1.24 (1.00–1.53) | 0.0494 | 0.1211 | 6/148/784 | 8/210/1392 | 1.34 (1.07–1.67) | 0.0111 | 0.0462 |
| rs1934956 | 10:96828160 | CYP2C8 | A/G | 0.455 | intron | 0.437/0.466 | 0.89 (0.793–0.998) | 0.0454 | 0.1211 | 172/475/291 | 351/796/462 | 0.87 (0.77–0.99) | 0.0324 | 0.1045 |
| rs2071426 | 10:96828323 | CYP2C8 | G/A | 0.068 | intron | 0.079/0.062 | 1.29 (1.04–1.61) | 0.0220 | 0.1075 | 2/144/792 | 8/184/1418 | 1.35 (1.06–1.70) | 0.0139 | 0.0533 |
| rs9332092 | 10:96696529 | CYP2C9 | G/A | 0.045 | upstream | 0.053/0.040 | 1.34 (1.03–1.75) | 0.0308 | 0.1115 | 0/100/835 | 0/130/1478 | 1.54 (1.15–2.06) | 0.0033 | 0.0226 |
| rs4918758 | 10:96697252 | CYP2C9 | G/A | 0.390 | upstream | 0.408/0.379 | 1.13 (1.007–1.270) | 0.0384 | 0.1115 | 149/467/321 | 222/776/612 | 1.18 (1.04–1.34) | 0.0102 | 0.0447 |
| rs2860905 | 10:96702295 | CYP2C9 | A/G | 0.096 | intron | 0.109/0.088 | 1.26 (1.044–1.526) | 0.0161 | 0.0954 | 10/184/744 | 14/255/1336 | 1.36 (1.11–1.66) | 0.0032 | 0.0226 |
| rs9332146 | 10:96722244 | CYP2C9 | A/G | 0.031 | intron | 0.023/0.035 | 0.65 (0.460–0.931) | 0.0176 | 0.0954 | 0/44/893 | 2/110/1496 | 0.65 (0.44–0.95) | 0.0256 | 0.0883 |
Abbreviations: Chr, chromosome; SNP, single-nucleotide polymorphism; Allele, minor/major allele; MAF, minor allele frequency; OR, odds ratios; 95% CI, 95% confidence interval; FDR, false discovery rate.
Note: The P-allele was derived from the comparison of the allele frequency between the GDM and control groups. P-genotype refers to the comparison of genotype distribution between the case group and control group, adjusted for maternal age, pre-pregnancy BMI, history of PCOS, history of GDM and family history of diabetes using logistic regression analysis in the additive genetic model; OR with 95% CI shows the association between the effect allele and GDM. FDR values < 0.05 are written in bold letters.
a Positions are based on the Human Genome version 19 (hg19), build 3.