Table 3.
Pre-transplant clinical and demographic factors, %
|
Delayed
|
Early
|
P value
|
Education | 0.14 | ||
Highschool or less | 62.6 | 50.7 | |
College degree or more | 14.7 | 23.4 | |
Substance use | |||
Smoking history | 55.1 | 57.3 | 0.15 |
Drinking history | 62.8 | 74.3 | 0.12 |
Sobriety period | < 0.01 | ||
< 6 mo | 22.4 | 59.0 | |
6 mo – 2 yrs | 53.0 | 26.2 | |
> 2 yrs | 23.6 | 14.8 | |
Psychosocial factors | |||
Depression history | 39.7 | 28.0 | 0.12 |
Trauma history | 9.0 | 2.4 | 0.07 |
Public insurance | 50.0 | 50.0 | 1.00 |
Non-English first language | 20.5 | 13.6 | 0.24 |
Lives with family | 78.2 | 80.2 | 0.75 |
Married/stable partner | 67.5 | 52.4 | 0.05 |
Unstable housing | 6.4 | 4.9 | 0.68 |
Military service history | 3.8 | 8.6 | 0.21 |
Worked within 1 mo | 7.7 | 22.2 | <0.01 |
Worked within 1 yr | 24.4 | 49.4 | <0.01 |
Clinical care | |||
Outpatient GI documentation | 83.3 | 78.0% | |
Ascites on diuretics | 90.7 | 90.3 | 0.94 |
Ascites with regular paracentesis | 32.0 | 25.0 | 0.35 |
On lactulose/rifaximin | 85.0 | 90.5 | 0.39 |
Midodrine | 42.9 | 46.0 | 0.81 |
Regular labs | n = 59 | n = 40 | |
Low albumin | 89.8 | 77.5 | 0.09 |
High ALT/AST | 93.2 | 87.5 | 0.31 |
High INR | 84.7 | 72.5 | 0.14 |
Prior decompensations | |||
Ascites | 96.2 | 87.8 | 0.05 |
Jaundice | 66.7 | 68.3 | 0.83 |
Variceal bleed | 35.9 | 29.3 | 0.37 |
Hepatic encephalopathy | 78.2 | 64.2 | 0.06 |
Hepatorenal syndrome | 35.9 | 31.7 | 0.58 |
Hepatic hydrothorax | 11.5 | 9.8 | 0.72 |
Spontaneous bacterial peritonitis | 21.8 | 24.4 | 0.68 |
Comparison of psychosocial and clinical data from prior to liver transplant evaluation (LTE) in patients with delayed compared to early LTE. Psychiatric comorbidities including depression and trauma occurred more in delayed LTE. Working history was strongly associated with timely referral. Data reported as percentages of group for categorical data; as average (standard deviation) for normally distributed continuous data. Comparisons were made using students T tests and comparison of proportions test. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GI: Gastrointestinal; INR: International normalized ratio.