Table 2.

Evaluation criteria.

A. Scoring Criteria for Swallowability
Score	Observation
1	Swallowed	No chewing took place during deglutition and no residuals of the solid were found during oral inspection.
2	Chewed/left over	Chewing was observed before deglutition and/or that the whole or parts of the solid were found in the mouth during oral inspection and/or some mini-tablets left over on the spoon (≥80% should have been swallowed).
3	Spat out	No deglutition took place and the solid was no longer in the child’s mouth.
4	Choked on	The solid was swallowed the wrong way or a cough was caused.
5	Refused to take	The child did not allow the investigator to place the solid in the mouth and/or <80% of mini-tablets swallowed.
B. Definition of acceptability derived from swallowability alone
	Criteria
Acceptable	Yes	Swallowability score was 1 or 2
	No	Swallowability score was >2 (3–5)
C. Scoring criteria for palatability
Score	Assessment	Interpretation
1	Pleasant	Positive hedonic pattern: Tongue protrusion, smack of mouth and lips, finger sucking, corner elevation
2	Neutral	Neutral mouth and body movements, and face expressions (irregular and involving lips)
3	Unpleasant	Negative aversive pattern: Gape, nose wrinkle, eye squinch, frown, grimace, head shake, arm flail
D. Scoring criteria for composite acceptability endpoint derived from palatability and swallowability
Palatability	Swallowability score
	1	2	≥3
Pleasant	High	Good	No
Neutral	Good	Low	No
Unpleasant	Low	No	No
E. Acceptability as composite acceptability endpoint
Yes: High/good
No: low/no