Table 4.
Drug adverse events in different treatment groups (n/N)
|
Group
|
500 mg b.i.d.
|
750 mg b.i.d.
|
500 mg t.i.d.
|
All
|
P
|
| Taste distortion | 2 | 6 | 8 | 16 | 0.060 |
| Nausea | 2 | 6 | 4 | 12 | 0.190 |
| Abdominal pain | 1 | 2 | 0 | 3 | 0.320 |
| Vomiting | 0 | 1 | 0 | 1 | 0.310 |
| Bloating | 3 | 0 | 1 | 4 | 0.290 |
| Diarrhea | 4 | 2 | 1 | 7 | 0.570 |
| Dizziness | 1 | 2 | 1 | 4 | 0.670 |
| Skin rash | 3 | 4 | 3 | 10 | 0.740 |
| Fatigue | 1 | 4 | 1 | 6 | 0.140 |
| Fever | 4 | 6 | 8 | 18 | 0.250 |
| Constipation | 1 | 1 | 0 | 2 | 0.630 |
| Decreased appetite | 0 | 3 | 7 | 10 | 0.009 |
| Chills | 0 | 1 | 0 | 1 | 0.310 |
| Melena | 0 | 0 | 1 | 1 | 0.310 |
| Abdominal discomfort1 | 2 | 0 | 1 | 3 | 0.480 |
| All2 | 15.3% (24/157) | 32.3% (38/118) | 30.3% (36/119) | 98/394 | 0.002 |
1
Abdominal discomfort, but not of specified.
2
The symptoms of a single adverse reaction are counted as 1, and a patient may have multiple adverse events.
P values were from two-side comparisons the differences among three treatment group. N: Total patient number; n: Patient number with side effects; 500 mg b.i.d.: Tetracycline twice daily; 750 mg b.i.d.: Tetracycline twice daily; 500 mg t.i.d.: Tetracycline three times daily.