Table 1.
DNA damage caused by 131I. (single-strand breaks (SSBs); double-strand breaks (DSBs); anti-reactive oxygen metabolites (Anti-ROMs); reactive oxygen metabolites-derived compounds (d-ROMs)).
| Subject | Dose of 131I | Test Site | Side Effects of 131I | Ref. |
|---|---|---|---|---|
| Thirty-one patients in hypothyroidism (HYPO group) and 31 patients in euthyroidism (rhTSH group) | 1850 MBq | blood | In the HYPO patients, the radiation exposure rate, chromosome breaks, SSBs, DSBs, total exchanges (DNA-1), transient unstable DNA damage, stable DNA damage, anti-reactive oxygen metabolites (Anti-ROMs), “FAST” antioxidants (Anti-ROMsF), polymorphisms, DNA mutation score↑ and d-ROMs, “SLOW” antioxidants (Anti-ROMsS)↓ at one week. d-ROMs and Anti-ROMsS↑ at 3 months compared to one week. |
[13] |
| Nineteen patients (16 women and three men) suffering from thyroid cancer | 2590 MBq | blood | MN and CA↑ and the in-serum uric acid concentration↑ after 1 month. Thiobarbituric acid-reactive products↓ after 6 months. |
[11] |
| Eleven patients already submitted to total thyroidectomy | Between 2.96 and 5.50 GBq | peripheral blood lymphocytes | MN and clastogenic factor↑ | [77] |
| Twenty-two DTC patients | 3.7 GBq | Peripheral blood lymphocytes | MN↑ | [78] |
| Ten patients suffering from thyroid cancer | 1850 MBq | Circulating blood lymphocytes | [75] | |
| A 34 year old male patient | 1780 MBq | Lymphocytes | [80] | |
| Twelve women with papillary or folhcular thyroid cancer | 3700–5500 MBq | Blood lymphocytes | Clastogenic effects, X chromosome-independent aneugenic activity↑ at 1 week after treatment. |
[81] |
| Fifty DTC patients | 3.7 GBq | Peripheral lymphocytes | CA↑ approx. 10 days after treatment | [82] |
| Nineteen DTC patients | 1734–2600 MBq | Blood lymphocytes | CA↑ | [84] |