Table 7.

Intratumoural microbiota that can affect chemotherapy response and toxicity

Intratumoural microbiota	Mechanism	Cancer	References
Lactobacillus	ABX can partially impair the function of cisplatin by upregulating the expression of VEGFA and downregulating the expression of BAX and CDKN1B	Lung cancer	[118]
Lactobacillus	Participating in some cellular protective processes and preventing cytokine induced epithelial cell damage	Colorectal cancer	[117]
Gamma Proteobacteria	By expressing the bacterial enzyme cytidine deaminase (CDD), chemotherapeutic drug gemcitabine is metabolized into its inactive form	Pancreatic ductal adenocarcinoma (PDA)	[21]