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. 2023 Jun 28;24:266. doi: 10.1186/s12859-023-05393-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Associating Immune Scores with Patient Survival. A Skin Cancer Patients treated with ICI dichotemized based on xCell derived Immune Scores as well as M2 Macrophage estimated from Cibersort. Patients with High Immune Score and Low M2 Macrophage were associated with better survival. B User Interface that access this function from the Shiny App is (1) Select Feature Condition to restrict to pretreated patients, (2) Multivariate Coxh Analysis, (3) Bivariate Interaction Survival Analysis, (4) Select Immune Score (on left) and M2 Macrophage (on right). The feature can be dichotemized “on-the-fly” if it is a continuous variable (4)