Figure 4.

The varied mechanisms of action and pathways engagement by various drugs to promote egress of AQH from the anterior chamber of the eye via the conventional TM/SC pathway and/or via the uveoscleral pathway to relieve the elevated IOP are depicted in Figure 4A. Moreover, drugs that inhibit the production of AQH (inflow inhibitors) are also shown in (A). (B) displays a list of genes that are impacted and/or are implicated in the etiology of glaucoma (POAG/cOHT) via TM, SC and/or both tissues. (A) is modified from Figure 1A, which was adapted from Refs. 99 and 100 (the author’s own recent publications). The small tabulate list shown in (B) is derived with gratitude from [25] under Creative Commons Attribution 4.0 International License and which is a Nature Communications article.