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. 2023 Jun 14;14:1151166. doi: 10.3389/fimmu.2023.1151166

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Copyright © 2023 Brauer, Maruta, Lisci, Strege, Oschlies, Nakamura, Böhm, Lehmberg, Brandhoff, Ehl, Parvaneh, Klapper, Fukuda, Griffiths, Hennies, Niehues and Ammann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lymph node biopsy (A) Lymph node biopsy of family member IV with classic Hodgkin lymphoma showing 1.) CD30 positive cells and 2.) LMP-EBV positive cells after hematoxylin and eosin (H&E) stain and 3.) EBER positive cells after in-situ hybridisation. (B) Lymph node histology of family member VI showing 1.) CD30 negative, 2.) CD20 positive and 3.) EBV negative NLPHL (nodular lymphocyte predominant Hodgkin lymphoma). LMP, latent membrane protein; EBV, Epstein-Barr Virus; EBER, Epstein-Barr virus (EBV)-encoded small RNAs.