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. 2023 Jun 14;17:1067098. doi: 10.3389/fnins.2023.1067098

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Copyright © 2023 Faber, Ballegaard, Ørsted, Eldrup, Karpatschof, Gyntelberg, Hecquet and Gjedde.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined groups. Intervention effect measured as the relation between changes in HbA1c after 6 months of intervention and baseline HbA1c with experimental and conventional treatment group members pooled, including individuals with a predefined minimum reduction of PPS ≥ 15 at the end of the intervention period (i.e., PPS reverters; N = 52), and individuals without this reduction (PPS non-reverters; N = 60). (A) shows PPS non-reverters. (B) shows PPS reverters (between-group difference signifcant at P < 0.0001). Regarding HbA1c change depicted on the y-axis, a positive value reflects a reduction in HbA1c.