Table 4. Average annual percentage change (AAPC) with confidence interval (CI) in colorectal cancer by age, sex, and tumor characteristics in North Rhine-Westphalia, Germany, 2008–2019.

	Younger patients				Older patients
	Males		Females		Males		Females
	AAPC	[95% CI]	AAPC	[95% CI]	AAPC	[95% CI]	AAPC	[95% CI]
Total	−0.5	[−1.3; 0.3]	−0.4	[−1.1; 0.3]	−2.6	[−3.3; −1.9]	−2.9	[−3.9; −2]
ICD-O-3 localizations
Proximal colon	1.4	[0; 2.8]	0.5	[−1.6; 2.8]	−0.5	[−1.3; 0.3]	0	[−0.6; 0.5]
Distal colon	1.1	[−0.3; 2.6]	0.8	[−0.6; 2.3]	−2.1	[−2.6; −1.6]	−3.1	[−4; −2.2]
Rectum	−0.9	[−2.1; 0.3]	−0.2	[−1.3; 0.9]	−3.6	[−2.2; −8.7]	−3.2	[−3.8; −2.6]
Not otherwise specified	−9.6	[−11.7; −7.5]	−9.7	[−11.7; −7.7]	−10.7	[−12; −9.5]	−9.7	[−11.2; −8.2]
Histological groups
Adenocarcinomas	−0.5	[−1.5; 0.4]	−0.7	[−1.3; −0]	−2.5	[−3; −2.1]	−2.4	[−2.8; −2]
Neuroendocrine tumors	8.4	[−1.6; 19.6]	12.2	[3.9; 21.2]	2.3	[0.5; 4.2]	3.7	[−1; 8.6]
Other unspecified malignant neoplasms	−3.1	[−10.6; 4.9]	−1.2	[−7; 4.9]	−6	[−9.3; −2.7]	−6.7	[−9.1; −4.2]
Tumor size
T1	4.6	[0.8; 8.5]	8.3	[1.5; 15.6]	2.9	[1.7; 4.1]	2.2	[0.4; 3.9]
T2	−1.4	[−3.7; 0.9]	0.3	[−2; 2.6]	−3	[−4.1; −1.8]	−2.6	[−3.5; −1.7]
T3	−0.9	[−2.5; 0.7]	−1.4	[−2.6; −0.3]	−3.4	[−4.5; −2.2]	−3.2	[−4.2; −2.3]
T4	−0.4	[−2.2; 1.4]	−0.2	[−2.1; 1.9]	−1.1	[−2.9; 0.7]	−1.5	[−3.3; 0.4]
Unknown	−1.5	[−4.6; 1.8]	−2.1	[−5.8; 1.8]	−3.8	[−6; −1.6]	−4.8	[−6.2; −3.4]
Histopathological grading
G1	8.8	[5.7; 12]	8.7	[4.7; 12.8]	6.5	[5.5; 7.5]	6.3	[4.6; 8.1]
G2	−0.4	[−1.5; 0.7]	0.1	[−0.9; 1.1]	−2.2	[−3.6; −0.8]	−2.7	[−3.1; −2.2]
G3/4	−3.9	[−5.3; −2.6]	−4.7	[−5.8; −3.6]	−5.3	[−6.1; −4.5]	−4.0	[−4.6; −3.4]
Unknown	−2.6	[−7.5; 2.4]	−2.2	[−5.3; 1.1]	−5.9	[−8.1; −3.6]	−6.2	[−9.1; −3.3]