Table 1.

Studies include ed.

Name	Country	Study Design	Period of Enrollment	FIGO Stage	No. of Participants	Treatment (Median Dose)	Mean FU * Months
Pirtoli 1980 ^ [26]	Italy	Retrospective observational monocenter study	1960–1974	-	43	External beam radiation therapy 4500–6000 rad in 5–6 weeks + boost dose 2000–3000 rad to vaginal vault	60
Kuten 1989 [27]	USA	Retrospective observational monocenter study	1959–1986	I–IV	51	Preoperative and/or postoperative external beam radiation therapy 3978 cGy and/or brachytherapy 3000 cGy	54
Sears 1994 [28]	USA	Prospective interventional monocenter study	1973–1991	I–IV	45	External beam radiation therapy 5000 cGy and/or brachytherapy 4000 cGy	89
Nag 1997 [29]	USA	Prospective interventional monocenter study	1989–1995	-	14	External beam radiation therapy 4500–5000 cGy and/or brachytherapy 3000 cGy	47
Pierga 1997 ^ [18]	France	Prospective interventional monocenter study	1992–1996	-	6	Doxorubicin, 5-fluorouracil, etoposide, and cisplatin	30
Wylie 2000 [30]	Canada	Prospective interventional monocenter study	1984–1988	I–II	58	External beam radiation therapy 8150 cGy	102
Smaniotto 2005 [15]	Italy	Prospective interventional monocenter study	1992–2003	-	30	5-fluorouracil, mitomycin C, external beam radiation therapy 4-week split course: 2340 + 2340 cGy and/or brachytherapy 2000–2500 cGy	27
Petignat 2006 [31]	Canada	Prospective interventional monocenter study	1997–2003	IB–IC	22	High-dose-rate interstitial brachytherapy 2600 cGy	32
Huh 2007 [32]	USA	Prospective interventional multicenter study	1975–2002	IA–IB–IC	69	External beam radiation therapy and/or brachytherapy	63
Attarian 2009 ^ [33]	Iran	Prospective interventional monocenter study	2004–2007	-	11	Carboplatin and Paclitaxel	30
Leslie 2013 [34]	USA	Prospective interventional monocenter study	-	-	30	Lapatinib	-
Vance 2016 ^ [35]	USA	Prospective interventional monocenter study	1989–2013	I–II	39	External beam radiation therapy 5470 cGy and/or brachytherapy 9430 cGy	56
Chapman 2017 [36]	USA	Prospective interventional monocenter study	2000–2010	I–III	30	Salvage high-dose-rate brachytherapy 6830 cGy and external beam radiation therapy in 1.8 Gy daily fractions to a total of 4500 or 5040 cGy	76
Kamran 2017 ^ [17]	USA	Retrospective case–control multicenter study	2005–2016	I–IV	66	High-dose-rate interstitial brachytherapy 7400 cGy	33
Francis 2019 ^ [37]	USA	Prospective interventional multicenter study	2000–2016	I–II	2691	Salvage external beam radiation therapy 4500 cGy	74

* Follow-Up. ^ Sub-analysis of the entire cohort.