Scheme 27.
Reagents and conditions: (i) H2O2, acetonitrile, r.t, 4 h; (ii) FeSO4.7H2O, MeOH, −5–0 °C, 8h, 57%; (iii) propargyl bromide, K2CO3, acetone, r.t, 4 h, 86%; (iv) R-N3, CuSO4, sodium ascorbate, MeOH/DCM (1:1), r.t, 10–60 min.
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