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The schematics illustrate the processes of AQH production and its removal from the anterior chamber of the eye via the conventional IOP-dependent outflow pathway (TM/SC) and the uveoscleral pathway. Furthermore, the mechanism of action of key approved medications to lower IOP by influencing the latter process and pathways is depicted in both (A) and (B). The red minus symbol denotes inhibition and the green plus symbol indicates stimulation or activation.
