Table 4.
Pharmacokinetics of CBD and THC in rat whole-blood and brain after a single oral dose of Cannabis sativa extract at 30 mg/kg (cannabidiol equivalent dose) in the solvents Cremophor EL [Kolliphor® EL, pH-range 6.0–8.0, Sigma Aldrich]/ethanol/saline solution (1:1:18) formulation and Rapae oleum.
| PK Parameter | CBD | THC | ||
|---|---|---|---|---|
| Rapae Oleum | Cremophor | Rapae Oleum | Cremophor | |
| Whoole blood | ||||
| Cmax (ng/mL) | 333.62 | 120.13 | 26.19 | 18.53 |
| Tmax (h) | 2 | 0.5 | 4 | 1 |
| CL (L/h) | 5.85 | 7.75 | 2.56 | 2.18 |
| AUC0–24 (ng/mL×h) | 1287.65 | 988.03 | 185.92 | 217.02 |
| MRT (h) | 4.03 | 12.01 | 5.75 | 12.69 |
| Terminal slope ke (L/h) | −0.15 | −0.11 | −0.18 | −0.11 |
| Vd (L) | 28.29 | 69.66 | 15.15 | 28.26 |
| AUC(CBD)/AUC(THC) | 6.93 | 4.55 | ||
| Brain | ||||
| Cmax (ng/mL) | 301.38 | 274.99 | 75.76 | 56.85 |
| Tmax (h) | 2 | 0.5 | 4 | 4 |
| CL (L/h) | 3.91 | 8.25 | 0.87 | 0.73 |
| AUC0–24 (ng/mL×h) | 1985.93 | 943.04 | 553.39 | 655.88 |
| MRT (h) | 7.76 | 6.19 | 7.19 | 5.11 |
| Terminal slope ke (L/h) | −0.10 | −0.15 | −0.11 | −0.20 |
| Vd (L) | 30.38 | 51.08 | 6.17 | 3.73 |
| AUC(CBD)/AUC (THC) | 3.59 | 1.44 | ||