Table 7.
THC and CBD mean concentration over time in rat brain and whole blood after a single oral dose of Cannabis sativa extract at 30 mg/kg (cannabidiol equivalent dose) in the solvents Cremophor EL [Kolliphor® EL, pH-range 6.0 – 8.0, Sigma Aldrich]/ethanol/saline solution (1:1:18) formulation and Rapae oleum.
| Tissue/Rapae Oleum | p-Value | Tissue/Cremophor | p-Value | ||||
|---|---|---|---|---|---|---|---|
| Blood/Rapae Oleum | THC | CBD | Blood/Cremophor | THC | CBD | ||
| 0.5 | 11.885 | 26.905 | 0.024 | 0.5 | 13.05 | 120.133 | 0.043 |
| 1 | 10.9508 | 106.9125 | 0.044 | 1 | 18.535 | 108.887 | 0.039 |
| 2 | 24.029 | 333.619 | 0.045 | 2 | 13.988 | 46.538 | 0.031 |
| 4 | 26.1975 | 153.554 | 0.039 | 4 | 8.008 | 35.125 | 0.036 |
| 6 | 10.259 | 37.584 | 0.033 | 6 | 9.045 | 31.416 | 0.032 |
| 24 | 0.445 | 2.759 | 0.040 | 24 | 3.788 | 12.315 | 0.031 |
| Brain/Rapae oleum | THC | CBD | Brain/Cremophor | THC | CBD | ||
| 0.5 | 3.719 | 23.327 | 0.040 | 0.5 | 18.575 | 274.994 | 0.046 |
| 1 | 43.593 | 65.391 | 0.013 | 1 | 49.521 | 213.491 | 0.035 |
| 2 | 75.768 | 301.388 | 0.034 | 2 | 56.85 | 81.1135 | 0.011 |
| 4 | 27.792 | 263.466 | 0.043 | 4 | 35.976 | 52.1185 | 0.011 |
| 6 | 3.7605 | 59.650 | 0.046 | 6 | 35.947 | 57.7145 | 0.014 |
| 24 | 0 | 9.797 | 0.05 | 24 | 1.154 | 3.604 | 0.030 |