TABLE 1.
Combination strategies for enhancing ferroptosis induced by ionizing radiation.
| Tumor type | Cell lines | Pathway involved | In vivo evaluation | Combination strategy | References |
|---|---|---|---|---|---|
| Nasopharyngeal carcinoma | C666-1 | FTO/OTUB1/SLC7A11 | HONE1R | IR/FB23-2 | Huang et al. (2023) |
| HONE1 | |||||
| C666-1R | |||||
| HONE1R | |||||
| Lung cancer | A549 | ANGPL4/GPX4/SLC7A11 | A549 | IR/ANGPTL4 enriched exosomes | Zhang et al. (2022) |
| H1299 | |||||
| Hepatocellular carcinoma | SK-Hep | SOCS2/SLC7A11 | SK-Hep-1 SK-Hep-1R | IR/SOCS2-overexpressing plasmid | Chen et al. (2023) |
| HepG2 | |||||
| SK-Hep-1R | |||||
| HepG2-1R | |||||
| Hepatocellular carcinoma | HepG2 | COMMD10/HIF1α/SLC7A11 | HepG2 | IR/Cu chelator | Yang et al. (2022) |
| MHCC-97H | |||||
| Oral squamous cell carcinoma | SCC15-S | GPX4 | SCC15-R | IR/Hyperbaric oxygen (HBO) | Liu et al. (2022) |
| SCC15-R | |||||
| Colorectal cancer | MC38 | ATF3-SLC7A11-GPX4 | MC38 | IR/niraparib | Shen et al. (2022) |
| CT26 | |||||
| HT29 | |||||
| Esophageal squamous cell carcinoma | KYSE30 | SCD1 | N.D. | IR/MF-438 | Luo et al. (2022) |
| KYSE70 | |||||
| KYSE140 | |||||
| KYSE150 | |||||
| KYSE410 | |||||
| KYSE450 | |||||
| KYSE510 |
N.D., not defined.