. Author manuscript; available in PMC: 2023 Jun 28.

Published in final edited form as: Occup Environ Med. 2019 Jul 13;76(11):827–837. doi: 10.1136/oemed-2018-105655

Table 3:

Cohort specific and Meta HR for the Association between Animal Farming and the Risk of Overall LHC

	Myeloid malignancies				Acute myeloid leukaemia /Myelodysplastic syndromes				Myeloproliferative neoplasms
	No.	HR^a	95% CI	I²	No.	HR^a	95% CI	I²	No.	HR^a	95% CI	I²
Any animal	537	0.91	0.68,1.22	62.9	329	0.85	0.58,1.50	63.5	150	0.97	0.63,1.50	38.1
Cattle	401	0.88	0.73,1.06	15.6	257	0.94	0.74,1.18	10.1	105	0.77	0.57,1.04	0.0
No. of cattle
<30	226	0.89	0.61,1.31	65.8	144	1.03	0.80,1.33	0.0	57	0.72	0.37,1.38	67.2
30+	122	0.72	0.51,1.01	0.0	84	0.94	0.63,1.41	0.0	33	0.44	0.18,1.06	33.1
P- trend			0.15				0.95				0.02
Dairy cattle	303	0.98	0.82,1.16	0.0	195	1.07	0.85,1.34	0.0	80	0.88	0.63,1.23	0.0
Beef cattle	196	0.88	0.73,1.06	0.0	123	0.95	0.69,1.33	39.3	44	0.69	0.37,1.27	57.1
Sheep/goats	213	0.97	0.65,1.45	66.3	118	0.91	0.71,1.15	0.0	71	1.32	0.67,2.59	65.3
No. of sheep/ goats
<35	124	1.02	0.78,1.34	48.4	73	no conv.	no conv.	no conv.	36	1.31	0.79,2.17	49.2
35+	89	1.14	0.88,1.47	0.0	45	no conv.	no conv.	no conv.	35	2.34	1.25,4.38	37.1
P- trend			0.47								<0.01
Pigs	242	0.89	0.73,1.09	16.7	163	0.95	0.73–1.24	20.7	58	0.76	0.54,1.09	0.0
No. of pigs
<35	163	0.91	0.70,1.19	43.8	114	0.98	0.69,1.40	52.9	40	0.85	0.60,1.22	0.0
35+	44	0.94	0.64,1.39	0.0	28	1.01	0.61,1.64	0.0	12	0.72	0.33,1.59	0.0
P- trend			0.48				0.87				0.27
Poultry	230	0.91	0.61,1.37	71.4	153	1.03	0.72,1.45	45.3	60	1.10	0.78,1.56	0.0
No. of poultry
<100	167	0.94	0.63,1.42	60.8	110	0.98	0.66,1.45	39.7	44	1.10	0.75,1.62	0.0
100+	61	1.03	0.72,1.48	26.8	42	1.15	0.81,1.63	0.0	16	1.08	0.61,1.93	0.0
P- trend			0.87				0.66				0.62
Livestock	523	0.92	0.73,1.15	43.0	319	0.84	0.61,1.17	52.8	147	1.01	0.70,1.46	19.3
No. of livestock
<100	130	0.85	0.59,1.22	0.0	92	0.90	0.35,2.30	68.1	25	0.58	0.16,2.18	41.7
100+	92	0.66	0.48,0.90	0.0	54	0.72	0.48,1.08	0.0	31	0.50	0.29,0.86	0.0
P- trend			0.01				0.04				0.02

Abbreviations: CI, confidence interval; HR, hazard ratio; No., number of exposed cases.; NA., not applicable as only one study contributed to this estimate; no conv; model did not converge in AGRICAN

AHS adjusted for sex, state, Chlorpyrifos, Terbufos, Dichlorvos, Dicamba, Glyphosate, Lindane, DDT, Aldicarb, Captan; AGRICAN adjusted for sex, retirement status, the number of crops for which farmer/worker personally applied pesticides ; CNAP adjusted for sex, Aldicarb, Lindane, DDT, Mancozeb