. Author manuscript; available in PMC: 2023 Jun 28.

Published in final edited form as: Occup Environ Med. 2019 Jul 13;76(11):827–837. doi: 10.1136/oemed-2018-105655

Table 5:

The Association between Farming any animal or specific animal species and the Risk of LHC subtypes, by Cohort

	Any animal									Cattle									Beef Cattle							Dairy cattle
	AGRICAN			CNAP			AHS			AGRICAN			CNAP			AHS			CNAP				AHS			AGRICAN			CNAP			AHS
	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI	No.	HR	95% CI
*Myeloid Malignancies*	153	0.96	0.67,1.38	304	1.10	0.87,1.40	80	0.68	0.48,0.95	142	0.74	0.50,1.10	206	0.99	0.80,1.22	53	0.78	0.55,1.09	146	0.91	0.73,1.13	50	0.81	0.58,1.14	122	1.05	0.76,1.46	175	0.96	0.78,1.18	6	0.80	0.35,1.83
MPNs	41	0.87	0.47,1.61	89	1.36	0.84,2.20	20	0.65	0.33,1.31	36	0.53	0.28,1.01	54	0.83	0.56,1.23	15	0.93	0.47,1.83	30	0.53	0.34,0.82	14	0.99	0.50,1.96	32	0.85	0.47,1.54	48	0.89	0.60,1.33	1	-	-
AML & MDs	34	0.70	0.35,1.42	176	1.35	1.05,1.44	43	0.56	0.36,0.87	103	0.90	0.52,1.55	125	1.06	0.81,1.40	29	0.71	0.45,1.12	95	1.08	0.82,1.44	28	0.76	0.48,1.20	89	1.20	0.79,1.82	106	1.02	0.77,1.33	3	-	-
*Lymphoid Malignancies*	411	1.24	0.98,1.58	1139	0.92	0.82,1.04	329	1.10	0.91,1.33	384	1.12	0.84,1.48	802	0.97	0.87,1.08	217	1.07	0.89,1.27	594	0.97	0.87,1.09	197	1.03	0.86,1.23	302	1.03	0.83,1.28	689	0.97	0.87,1.07	25	1.01	0.67,1.51
NHL	399	1.28	1.00,1.64	1087	0.92	0.81,1.04	307	1.10	0.90,1.33	373	1.14	0.86,1.51	764	0.97	0.87,1.08	204	1.07	0.89,1.29	564	0.96	0.85,1.08	158	1.03	0.86,1.25	293	1.04	0.83,1.29	657	0.96	0.86,1.08	23	1.00	0.65,1.52
NHL B-CELL	359	1.29	0.99,1.67	1012	0.92	0.81,1.04	288	1.08	0.88,1.31	337	1.14	0.83,1.55	714	0.97	0.87,1.09	194	1.09	0.90,1.32	523	0.95	0.84,1.07	175	1.04	0.86,1.26	265	1.04	0.83,1.30	613	0.97	0.86,1.08	23	1.07	0.70,1.63
CLL/SLL	83	1.15	0.68,1.92	199	0.86	0.65,1.14	74	0.90	0.62,1.32	78	0.96	0.54,1.72	133	0.86	0.66,1.10	50	0.96	0.67,1.39	93	0.77	0.58,1.01	47	0.98	0.68,1.42	57	0.77	0.47,1.26	122	1.00	0.77,1.29	3	-	-
Lymphoplasmacytic lymphoma	34	1.25	0.55,2.86	70	1.06	0.62,1.80	3	-	-	32	1.04	0.42,2.57	51	1.07	0.68,1.69	1	-	-	42	1.26	0.79,2.00	0	-	-	23	0.84	0.43,1.66	41	0.89	0.57,1.40	1	-	-
DLBCL	69	1.52	0.81,2.83	177	0.93	0.69,1.25	71	1.24	0.82,1.86	63	1.12	0.59,2.11	120	0.91	0.69,1.19	48	1.20	0.82,1.77	88	0.90	0.68,1.28	42	1.09	0.74,1.61	49	1.06	0.63,1.80	105	0.95	0.73,1.25	6	1.14	0.50,2.62
MZL	27	3.71	0.87,15.81	32	1.07	0.52,2.21	9	1.14	0.34,3.86	27	-	-	24	1.23	0.64,2.35	7	1.45	0.48,4.38	15	0.86	0.43,1.73	6	1.20	0.40,3.61	26	19.95	1.21,99.10	19	0.99	0.51,1.89	2	-	-
FL	29	1.09	0.47,2.54	93	1.37	0.85,2.21	43	1.25	0.72,2.19	26	0.61	0.26,1.40	74	1.61	1.08,2.41	32	1.50	0.91,2.49	52	1.28	0.85,1.92	28	1.31	0.79,2.18	22	0.79	0.38,1.65	65	1.53	1.03,2.27	6	2.13	0.91,4.98
Multiple myeloma / Plasma-cell Leukaemia	94	1.09	0.67,1.78	258	0.90	0.71,1.15	51	0.90	0.59,1.38	89	1.18	0.62,2.26	191	1.10	0.88,1.38	31	0.81	0.52,1.25	140	1.09	0.86,1.38	30	0.87	0.56,1.35	71	1.09	0.67,1.77	160	1.02	0.82,1.28	1	-	-
NHL T-cell	23	0.92	0.36,2.34	58	1.21	0.70,2.10	13	1.48	0.50,4.38	21	1.21	0.36,4.00	37	0.94	0.58,1.52	6	0.68	0.25,1.84	30	1.17	0.71,1.94	6	0.80	0.29,2.16	17	1.10	0.39,3.14	34	1.08	0.67,1.75	0	-	-

	Sheep/goats									Pigs									Livestock									Poultry
	AGRICAN			CNAP			AHS			AGRICAN			CNAP			AHS			AGRICAN			CNAP			AHS			AGRICAN			CNAP			AHS
	No.	HR^a	95% CI	No.	HR^b	95% CI	No.	HR^c	95% CI	No.	HR^a	95% CI	No.	HR^b	95% CI	No.	HR^c	95% CI	No.	HR^a	95% CI	No.	HR^b	95% CI	No.	HR^c	95% CI	No.	HR^a	95% CI	No.	HR^b	95% CI	No.	HR^c	95% CI
*Myeloid Neoplasms*	39	0.76	0.49,1.16	174	1.15	0.94,1.40	2	-	-	79	0.75	0.52,1.08	128	1.01	0.81,1.27	35	0.79	0.53,1.19	149	0.95	0.67,1.34	259	1.06	0.84,1.34	79	0.72	0.51,1.00	99	0.81	0.58,1.14	123	1.24	0.99,1.54	8	0.58	0.29,1.19
AML & MDs	27	0.73	0.43,1.23	70	0.96	0.74,1.26	1	-	-	60	0.77	0.48,1.24	82	1.14	0.85,1.52	21	0.80	0.48,1.36	107	0.97	0.63,1.48	122	0.99	0.73,1.35	42	0.58	0.37,0.92	71	0.79	0.51,1.20	75	1.28	0.96,1.71	7	0.94	0.43,2.03
MPNs	11	0.87	0.42,1.78	60	1.75	1.20,2.57	1	-	-	18	0.68	0.30,1.52	33	0.87	0.56,1.35	7	0.53	0.22,1.26	40	0.87	0.48,1.60	87	1.32	0.83,2.11	20	0.71	0.35,1.43	26	0.90	0.47,1.71	34	1.20	0.79,1.83	-	-	-
*Lymphoid Neoplasms*	96	0.75	0.52,1.07	607	0.94	0.85,1.04	22	1.36	0.88,2.09	209	0.88	0.72,1.08	452	0.86	0.76,0.97	159	1.15	0.94,1.41	403	1.17	0.93,1.47	1119	0.94	0.84,1.06	316	1.06	0.88,1.28	245	0.92	0.71,1.17	429	1.04	0.93,1.17	52	1.20	0.90,1.60
NHL	91	0.72	0.50,1.04	576	0.93	0.83,1.03	22	1.46	0.95,2.25	204	0.89	0.72,1.09	438	0.88	0.78,1.00	146	1.14	0.92,1.41	391	1.20	0.94,1.51	1068	0.94	0.94,1.06	296	1.07	0.88,1.30	238	0.91	0.72,1.17	408	1.04	0.92,1.17	49	1.21	0.90,1.63
NHL B-cell	82	0.72	0.51,1.02	543	0.95	0.85,1.06	21	1.48	0.95,2.31	181	0.87	0.70,1.08	410	0.88	0.78,1.00	136	1.12	0.90,1.40	352	1.18	0.92,1.51	994	0.93	0.93,1.06	279	1.07	0.88,1.31	213	0.90	0.69,1.18	381	1.04	0.92,1.17	44	1.14	0.84,1.56
CLL/SLL	21	0.82	0.45,1.51	102	0.94	0.73,1.21	4	-	-	49	1.16	0.72,1.86	88	0.91	0.69,1.21	40	1.20	0.80,1.80	81	0.92	0.57,1.48	193	0.85	0.65,1.12	74	0.97	0.66,1.42	52	0.97	0.56,1.66	81	1.09	0.84,1.43	6	0.59	0.26,1.35
Lymphoplasmacytic lymphoma	7	0.67	0.24,1.91	37	0.99	0.64,1.53	1	-	-	12	0.51	0.21,1.21	28	0.86	0.53,1.40	2	-	-	34	1.37	0.60,3.14	69	1.09	0.65,1.84	3	-	-	14	0.48	0.22,1.02	34	1.55	0.99,2.42	1	-	-
DLBCL	18	0.84	0.39,1.80	96	0.95	0.73,1.25	2	-	-	37	1.05	0.60,1.85	76	1.02	0.76,1.37	33	1.24	0.79,1.95	68	1.50	0.82,2.75	175	0.97	0.72,1.30	67	1.14	0.76,1.71	39	0.95	0.55,1.63	66	1.07	0.80,1.43	16	1.78	1.05,3.04
MZL	6	0.85	0.25,2.85	14	0.60	0.31,1.16	2	-	-	13	1.03	0.41,2.60	9	0.67	0.31,1.46	4	-	-	27	4.15	0.97,17.68	31	1.00	0.49,2.04	9	1.21	0.36,4.13	19	2.08	0.67,6.44	12	1.23	0.62,2.44	1	-	-
FL	3		-	46	0.93	0.63,1.36	1	-	-	11	0.45	0.20,1.06	37	0.99	0.65,1.51	17	0.80	0.44,1.46	28	1.03	0.46,2.30	93	1.49	0.92,2.41	42	1.27	0.73,2.22	16	0.61	0.23,1.61	31	0.96	0.63,1.48	4	-	-
Multiple myeloma / Plasma cell Leukaemia	21	0.70	0.42,1.16	142	0.96	0.77,1.19	8	3.54	1.68,7.46	50	0.89	0.56,1.41	99	0.84	0.66,1.08	26	1.39	0.84,2.29	91	1.01	0.63,1.61	255	0.94	0.74,1.20	48	0.86	0.56,1.32	60	0.95	0.53,1.73	90	0.96	0.75,1.23	8	0.98	0.48,2.04
NHL T,cell	6	0.84	0.20,3.51	25	0.69	0.42,1.13	1	-	-	15	1.71	0.58,5.04	22	0.99	0.58,1.69	7	1.41	0.50,3.99	23	1.00	0.39,2.56	57	1.22	0.71,2.09	12	1.20	0.42,3.39	16	1.48	0.57,3.86	22	1.23	0.74,2.06	3	-	-

Abbreviations: CI, confidence interval; HR, hazard ratio; MPNS, Myeloproliferative Neoplasms; AML, Acute myeloid leukaemia; MDS, Myelodysplastic syndrome; NHL, Non Hodgkin lymphoma; CCL/SLL, Chronic/small lymphocytic leukaemia/lymphoma; DLBCL, Diffuse large B-cell lymphoma, MZL, Marginal zone lymphoma; FL, Follicular lymphoma, No., number of exposed cases, - < 6 exposed cases or 0 non exposed cases

HR: AGRICAN - Cox Regression adjusted for: sex, retirement status, the number of crops for which farmer/worker personally applied pesticides

HR: CNAP - Myeloid malignancies - Cox Regression adjusted for: sex, Aldicarb, Lindane, DDT, Mancozeb

HR: CNAP - Lymphoid malignancies s - Cox Regression adjusted for: sex, Dichlorvos, Aldicarb, Lindane, DDT, Deltametrin, Mancozeb, Linuron, Glyphosate

HR: AHS - Myeloid malignancies - Cox Regression adjusted for: sex, state, Chlorpyrifos, Terbufos, Dichlorvos, Dicamba, Glyphosate, Lindane, DDT, Aldicarb, Captan

HR: AHS - Lymphoid malignancies - Cox Regression adjusted for: sex, state, Terbufos, Lindane, DDT, Permethrin, Dicamba, Parathion, Carbaryl