TABLE 2.

Membrane-active small molecules against S. aureus

Compound name	Type of Molecules	MIC (μg/mL)	Organism	References
Dialkyl cationic amphiphiles	Peptide mimics	0.5−4	S. aureus and MRSA	84
Structural organophosphorus aminopyrimidines	Peptide mimics	4	MRSA	85
Polyphenylglyoxamide-based small molecular peptidomimetics	Peptide mimics	2.9−5.6	S. aureus	183
Honokiol/magnolol amphiphiles	Peptide mimics	0.5−2	MRSA clinical isolates	113
Aryl-based synthetic mimics of antimicrobial peptides (SMAMPs)	Peptide mimics	3.13	S. aureus	88
Hydantoin derivatives	Peptide mimics	0.5−3.12	MRSA	89
l-lysine-based lipidated biphenyls	Peptide mimics	3.1	S. aureus ATCC and MRSA	90
Dimeric lysine alkylamides	Peptide mimics	0.75−1.5 1.5−3 3−6	MRSA	81
Cationic deacetyl linezolid derivatives	Peptide mimics	2−4	MRSA Clinical isolates	92
Acetanilide	Peptide mimics	1	MRSA	91
Porphyrin antibacterial agent	Repurposed drug	4	S. aureus SH1000	191
NH125 (1-hexadecyl-2-methyl-3-(phenylmethyl))-1H-imidazolium iodide	Repurposed drug	1	MRSA-MW2 BAA-1707	25
Veterinary drug oxyclozanide	Repurposed drug	4	MRSA	96
Bithionol-anthelmintic drug	Repurposed drug	0.5−2	MRSA-MW2 BAA-1707 and VRSA1	7
PQ401 (diaryl urea)	Repurposed drug	4	MRSA and VRSA	98
α-mangostin	Natural molecules	0.78−3.125	S. aureus ATCC 29213 and MRSA clinical isolates	105
α-mangostin (hydrophobic scaffold of xanthone)	Natural molecules	0.5−3	S. aureus DM4001 clinical isolates	106
Nonpeptidic amphiphilic xanthone derivatives of α-mangostin	Natural molecules	1.56−3.125	MRSA clinical isolates	108
Nisin + Cinnamaldehyde	Natural molecules	0.1875 + 0.375	S. aureus ATCC 29213	103
Licochalcone E Licochalcone C Licochalcone A Glabrol	Natural molecules	4 4 2 2	S. aureus ATCC 29213 and MRSA T144	109
Balsacone C	Natural molecules	3–11.6	Clinical isolates of MRSA and Methicillin sensitive Staphylococcus aureus	111
Natural berberine-hybridized benzimidazole derivative 2,4-dichlorobenzyl	Natural molecules	0.008–0.470	S. aureus ATCC 29213 and MRSA N315	110