Table 2.
Breast cancer events after completed neoadjuvant chemotherapy according to mammographic density assessed with Breast Imaging-Reporting and Data System (BI-RADS) at diagnosis.
| BI-RADS a | BI-RADS b | BI-RADS c | BI-RADS d | P value | ||
|---|---|---|---|---|---|---|
| Number of patients | 16 | 120 | 140 | 26 | ||
| Status | Alive | 13 (81.3) | 87 (72.5) | 114 (81.4) | 14 (53.8) | 0.043* |
| Primary breast cancer death | 2 (12.5) | 27 (22.5) | 25 (17.9) | 10 (38.5) | ||
| Death, other | 1 (6.3) | 5 (4.2) | 1 (0.7) | 2 (7.7) | ||
| Missing | 1 (0.8) | |||||
| New breast cancer | Yes | 2 (12.5) | 2 (1.7) | 4 (2.9) | 0.067* | |
| No | 14 (87.5) | 117 (97.5) | 136 (97.1) | 26 (100) | ||
| Missing | 1 (0.8) | |||||
| Recurrence | Yes | 5 (31.3) | 33 (27.5) | 37 (26.4) | 11 (42.3) | 0.425* |
| No | 11 (68.8) | 85 (70.8) | 103 (73.6) | 15 (57.7) | ||
| Missing | 2 (1.7) | |||||
| Age at recurrence | Median (IQR) | 61 (61–74) | 63 (51–71) | 52 (43–63) | 49 (42–60) | 0.017** |
| Time to recurrence (years) | Median (IQR) | 5.11 (2.38–8.40) | 2.34 (1.60–5.09) | 2.80 (1.53–5.67) | 1.90 (1.30–4.08) | 0.313** |
| Recurrence location | Local | 3 (2.1) | 0.212* | |||
| Locoregional | 1 (6.3) | 2 (1.7) | 1 (3.8) | |||
| Distant | 4 (25.0) | 31 (25.8) | 34 (24.3) | 10 (38.5) | ||
| No | 11 (68.8) | 85 (70.8) | 103 (73.6) | 15 (57.7) | ||
| Missing | 2 (1.7) | |||||
| Age at breast cancer death | Median (IQR) | 63*** | 64 (53–72) | 53 (44–69) | 51 (42–61) | 0.216** |
| Time to breast cancer death (years) | Median (IQR) | 4.76c | 3.89 (2.10–5.29) | 4.21 (1.46–6.17) | 3.37 (2.39–6.87) | 0.825** |
*Chi-square test.
**Kruskal Wallis test.
***Median only due to two events.
Time to recurrence = time from primary breast cancer diagnosis to recurrence diagnosis. Time to breast cancer death = time from primary breast cancer diagnosis to breast cancer-specific death.
IQR, interquartile range.