Table 1.

Association of DEPs with pathways included in the KEGG collection and statistical significance as calculated by tools available at DAVID [https://david.ncifcrf.gov/tools.jsp], accessed on 17 October 2022. Shared pathways are in italic.

BT474 wt vs. Tz-R			MDA-MB-361 wt vs. Tz-R			SKBR-3 wt vs. Tz-R
KEGG Pathway	% of DEPs	p-Value	KEGG Pathway	% of DEPs	p-Value	KEGG Pathway	% of DEPs	p-Value
Metabolic pathways	18.6	5.00 × 10−5	Chronic myeloid leukemia	2.9	1.40 × 10−2	Metabolic pathways	28	7.00 × 10−3
Biosynthesis of cofactors	4.3	5.00 × 10−3	TGF-beta signaling pathway	2.9	2.50 × 10−2	Thyroid hormone signaling pathway	6	1.10 × 10−2
			Metabolic pathways	17	4.30 × 10−2	Glycerophospholipid metabolism	5	2.40 × 10−2
			Proteoglycans in cancer	5	4.90 × 10−2