TABLE 1.

Bacteria and phages used in this study

Strain	Description (citation)
Bacteria
BW25113	E. coli K-12, a common laboratory strain and parent of the Keio knockout collection; lacks O-antigen and was derived from ancestral K-12 strain EMG2 (26)
JW5503-1	ΔtolC732:kan (40)
AB229	ΔtolC732:kan pCA24N::tolC, plasmid from reference 41
AB279	Evolved from BW25113, Pop+2 isolate, day 10. Contains a tolC mutation resulting in an amino acid substitution of tyrosine to aspartic acid at position 283 (8)
Phages
U136B	Environmental isolate from a swine farm (8, 11)
ET003	Evolved U136B mutant, Pop+1 isolate, day 5
ET004	Evolved U136B mutant, Pop+2 isolate, day 5
ET005	Evolved U136B mutant, Pop+3 isolate, day 5
ET006	Evolved U136B mutant, Pop+4 isolate, day 5
ET007	Evolved U136B mutant, Pop+5 isolate, day 5
ET008	Evolved U136B mutant, Pop+6 isolate, day 5
ET009	Evolved U136B mutant, Pop+7 isolate, day 5
ET010	Evolved U136B mutant, Pop+8 isolate, day 5
ET011	Evolved U136B mutant, Pop+9 isolate, day 5
ET012	Evolved U136B mutant, Pop+10 isolate, day 5
RB-020	Evolved U136B mutant, Pop+2 isolate, day 10
RB-022	Evolved U136B mutant, Pop+4 isolate, day 10
RB-024	Evolved U136B mutant, Pop+6 isolate, day 10
RB-028	Evolved U136B mutant, Pop+8 isolate, day 10
ET013	Evolved U136B mutant, Pop+9 isolate, day 10