Scheme 6.
Improved synthesis for 1S,5R,9S-C9-hydroxypropyl-5-phenylmorphan 39. Reactions and conditions: (a) BBr3, DCM, −78 °C→rt, 1 h, 59%; (b) i. 5% Pd/C, EtOH, H2, 50 psi, rt, 1 h, ii. LiAlH4, THF, 0 °C→rt, 1 h, 72%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.